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### Running command:
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###   /Library/Frameworks/R.framework/Resources/bin/R CMD check --install=check:tidybulk.install-out.txt --library=/Library/Frameworks/R.framework/Resources/library --no-vignettes --timings tidybulk_1.21.0.tar.gz
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* using log directory ‘/Users/biocbuild/bbs-3.22-bioc/meat/tidybulk.Rcheck’
* using R version 4.5.1 (2025-06-13)
* using platform: x86_64-apple-darwin20
* R was compiled by
    Apple clang version 14.0.0 (clang-1400.0.29.202)
    GNU Fortran (GCC) 14.2.0
* running under: macOS Monterey 12.7.6
* using session charset: UTF-8
* using option ‘--no-vignettes’
* checking for file ‘tidybulk/DESCRIPTION’ ... OK
* checking extension type ... Package
* this is package ‘tidybulk’ version ‘1.21.0’
* package encoding: UTF-8
* checking package namespace information ... OK
* checking package dependencies ... OK
* checking if this is a source package ... OK
* checking if there is a namespace ... OK
* checking for hidden files and directories ... OK
* checking for portable file names ... OK
* checking for sufficient/correct file permissions ... OK
* checking whether package ‘tidybulk’ can be installed ... OK
* checking installed package size ... OK
* checking package directory ... OK
* checking ‘build’ directory ... OK
* checking DESCRIPTION meta-information ... OK
* checking top-level files ... OK
* checking for left-over files ... OK
* checking index information ... OK
* checking package subdirectories ... OK
* checking code files for non-ASCII characters ... OK
* checking R files for syntax errors ... OK
* checking whether the package can be loaded ... OK
* checking whether the package can be loaded with stated dependencies ... OK
* checking whether the package can be unloaded cleanly ... OK
* checking whether the namespace can be loaded with stated dependencies ... OK
* checking whether the namespace can be unloaded cleanly ... OK
* checking whether startup messages can be suppressed ... OK
* checking dependencies in R code ... OK
* checking S3 generic/method consistency ... OK
* checking replacement functions ... OK
* checking foreign function calls ... OK
* checking R code for possible problems ... NOTE
.adjust_abundance_se: no visible binding for global variable ‘x’
.aggregate_duplicates_se: no visible binding for global variable
  ‘group_name’
.aggregate_duplicates_se: no visible binding for global variable
  ‘group’
.deconvolve_cellularity_se: no visible binding for global variable
  ‘X_cibersort’
.describe_transcript_SE: no visible binding for global variable
  ‘transcript’
.describe_transcript_SE: no visible binding for global variable
  ‘description’
.identify_abundant: no visible binding for global variable ‘.abundant’
.keep_abundant: no visible binding for global variable ‘.abundant’
.pivot_sample: no visible binding for global variable ‘.’
.quantile_normalise_abundance: no visible binding for global variable
  ‘x’
.quantile_normalise_abundance_se: no visible binding for global
  variable ‘x’
.resolve_complete_confounders_of_non_interest: no visible global
  function definition for ‘DataFrame’
.resolve_complete_confounders_of_non_interest_df: no visible global
  function definition for ‘combn’
.resolve_complete_confounders_of_non_interest_df: no visible global
  function definition for ‘ends_with’
.resolve_complete_confounders_of_non_interest_df: no visible binding
  for global variable ‘value’
.resolve_complete_confounders_of_non_interest_df: no visible binding
  for global variable ‘name’
.scale_abundance: no visible binding for global variable ‘x’
.scale_abundance: no visible binding for global variable ‘multiplier’
.scale_abundance_se: no visible binding for global variable ‘x’
.test_differential_abundance_se: no visible binding for global variable
  ‘.contrasts’
.test_differential_abundance_se: no visible binding for global variable
  ‘action’
.test_differential_cellularity: no visible binding for global variable
  ‘X_cibersort’
.test_differential_cellularity_se: no visible binding for global
  variable ‘X_cibersort’
.test_differential_cellularity_se: no visible binding for global
  variable ‘cell_type’
.test_differential_cellularity_se: no visible binding for global
  variable ‘prop’
.test_differential_cellularity_se: no visible binding for global
  variable ‘.cell_type’
.test_gene_enrichment_SE: no visible global function definition for
  ‘buildCustomIdx’
.test_gene_enrichment_SE: no visible global function definition for
  ‘buildIdx’
.test_gene_enrichment_SE: no visible global function definition for
  ‘egsea’
.test_gene_enrichment_SE: no visible binding for global variable
  ‘pathway’
.test_gene_enrichment_SE: no visible binding for global variable
  ‘data_base’
.test_gene_enrichment_SE: no visible binding for global variable
  ‘web_page’
.test_gene_overrepresentation: no visible binding for global variable
  ‘my_do_test’
.test_gene_overrepresentation_SE: no visible binding for global
  variable ‘my_do_test’
.test_gene_rank: no visible global function definition for
  ‘with_groups’
.test_gene_rank: no visible global function definition for ‘desc’
.test_gene_rank_SE: no visible global function definition for ‘desc’
.test_stratification_cellularity: no visible binding for global
  variable ‘X_cibersort’
.test_stratification_cellularity_SE: no visible binding for global
  variable ‘X_cibersort’
.test_stratification_cellularity_SE: no visible binding for global
  variable ‘.cell_type’
add_scaled_counts_bulk.calcNormFactor: no visible binding for global
  variable ‘transcript’
aggregate_duplicated_transcripts_DT: no visible binding for global
  variable ‘.abundance_scaled’
aggregate_duplicated_transcripts_bulk: no visible binding for global
  variable ‘.abundance_scaled’
aggregate_duplicated_transcripts_bulk: no visible binding for global
  variable ‘n_aggr’
aggregate_duplicated_transcripts_bulk: no visible global function
  definition for ‘where’
as_matrix: no visible binding for global variable ‘variable’
call_core: no visible binding for global variable ‘nulldist’
change_reserved_column_names: no visible binding for global variable
  ‘.’
check_if_duplicated_genes: no visible binding for global variable
  ‘transcript’
check_if_duplicated_genes: no visible binding for global variable ‘read
  count’
counts_scaled_exist_SE: no visible binding for global variable
  ‘tt_columns’
counts_scaled_exist_SE: no visible binding for global variable ‘.’
create_tt_from_bam_sam_bulk: no visible binding for global variable ‘.’
create_tt_from_bam_sam_bulk: no visible binding for global variable
  ‘temp’
create_tt_from_bam_sam_bulk: no visible binding for global variable
  ‘Status’
create_tt_from_bam_sam_bulk: no visible binding for global variable
  ‘counts’
create_tt_from_bam_sam_bulk: no visible binding for global variable
  ‘GeneID’
create_tt_from_bam_sam_bulk: no visible binding for global variable
  ‘genes’
create_tt_from_bam_sam_bulk: no visible binding for global variable
  ‘samples’
create_tt_from_bam_sam_bulk: no visible binding for global variable
  ‘transcript’
eliminate_sparse_transcripts: no visible global function definition for
  ‘add_count’
eliminate_sparse_transcripts: no visible binding for global variable
  ‘my_n’
entrez_over_to_gsea: no visible global function definition for
  ‘packageVersion’
entrez_over_to_gsea: no visible binding for global variable
  ‘gs_collection’
entrez_over_to_gsea: no visible binding for global variable ‘test’
entrez_over_to_gsea: no visible binding for global variable ‘geneID’
entrez_rank_to_gsea: no visible binding for global variable
  ‘gs_collection’
entrez_rank_to_gsea: no visible binding for global variable ‘.’
entrez_rank_to_gsea: no visible binding for global variable ‘ncbi_gene’
entrez_rank_to_gsea: no visible binding for global variable ‘fit’
error_if_duplicated_genes: no visible binding for global variable
  ‘transcript’
error_if_duplicated_genes: no visible binding for global variable ‘read
  count’
error_if_duplicated_genes: no visible global function definition for
  ‘desc’
error_if_log_transformed: no visible binding for global variable ‘m’
fill_NA_matrix_with_factor_colwise: no visible binding for global
  variable ‘.’
fill_NA_using_formula: no visible binding for global variable ‘NUL’
fill_NA_using_formula: no visible binding for global variable ‘ct_data’
fill_NA_using_formula: no visible binding for global variable
  ‘library_size__’
fill_NA_using_formula: no visible binding for global variable
  ‘cov_data’
filter_genes_on_condition: no visible binding for global variable
  ‘.feature’
get_abundance_norm_if_exists: no visible binding for global variable
  ‘.abundance_scaled’
get_adjusted_counts_for_unwanted_variation_bulk: no visible binding for
  global variable ‘.’
get_adjusted_counts_for_unwanted_variation_bulk: no visible global
  function definition for ‘all_of’
get_assay_scaled_if_exists_SE: no visible binding for global variable
  ‘tt_columns’
get_assay_scaled_if_exists_SE: no visible binding for global variable
  ‘.abundance_scaled’
get_cell_type_proportions: no visible binding for global variable ‘.’
get_clusters_SNN_bulk: no visible binding for global variable
  ‘seurat_clusters’
get_clusters_SNN_bulk_SE: no visible binding for global variable ‘.’
get_clusters_SNN_bulk_SE: no visible binding for global variable
  ‘seurat_clusters’
get_clusters_kmeans_bulk: no visible binding for global variable ‘.’
get_clusters_kmeans_bulk: no visible binding for global variable
  ‘cluster’
get_clusters_kmeans_bulk: no visible binding for global variable
  ‘cluster kmeans’
get_clusters_kmeans_bulk_SE: no visible binding for global variable ‘.’
get_clusters_kmeans_bulk_SE: no visible binding for global variable
  ‘cluster’
get_differential_transcript_abundance_bulk: no visible binding for
  global variable ‘.’
get_differential_transcript_abundance_bulk_SE: no visible binding for
  global variable ‘.’
get_differential_transcript_abundance_bulk_voom: no visible binding for
  global variable ‘.’
get_differential_transcript_abundance_bulk_voom_SE: no visible binding
  for global variable ‘.’
get_differential_transcript_abundance_deseq2: no visible binding for
  global variable ‘counts’
get_differential_transcript_abundance_deseq2: no visible binding for
  global variable ‘.’
get_differential_transcript_abundance_deseq2_SE: no visible binding for
  global variable ‘.’
get_differential_transcript_abundance_glmmSeq: no visible binding for
  global variable ‘tagwise.dispersion’
get_differential_transcript_abundance_glmmSeq: no visible binding for
  global variable ‘.’
get_differential_transcript_abundance_glmmSeq_SE: no visible binding
  for global variable ‘tagwise.dispersion’
get_differential_transcript_abundance_glmmSeq_SE: no visible binding
  for global variable ‘.’
get_reduced_dimensions_MDS_bulk: no visible binding for global variable
  ‘Component’
get_reduced_dimensions_MDS_bulk: no visible binding for global variable
  ‘Component value’
get_reduced_dimensions_MDS_bulk_SE: no visible binding for global
  variable ‘Component’
get_reduced_dimensions_MDS_bulk_SE: no visible binding for global
  variable ‘Component value’
get_reduced_dimensions_PCA_bulk: no visible binding for global variable
  ‘sdev’
get_reduced_dimensions_PCA_bulk: no visible binding for global variable
  ‘name’
get_reduced_dimensions_PCA_bulk: no visible binding for global variable
  ‘value’
get_reduced_dimensions_PCA_bulk: no visible binding for global variable
  ‘x’
get_reduced_dimensions_PCA_bulk_SE: no visible binding for global
  variable ‘sdev’
get_reduced_dimensions_PCA_bulk_SE: no visible binding for global
  variable ‘name’
get_reduced_dimensions_PCA_bulk_SE: no visible binding for global
  variable ‘value’
get_reduced_dimensions_PCA_bulk_SE: no visible binding for global
  variable ‘x’
get_reduced_dimensions_TSNE_bulk: no visible binding for global
  variable ‘Y’
get_reduced_dimensions_TSNE_bulk_SE: no visible binding for global
  variable ‘Y’
get_reduced_dimensions_UMAP_bulk_SE: no visible binding for global
  variable ‘x’
get_rotated_dimensions: no visible binding for global variable ‘value’
get_rotated_dimensions: no visible binding for global variable ‘rotated
  dimensions’
get_scaled_counts_bulk: no visible binding for global variable ‘med’
get_scaled_counts_bulk: no visible binding for global variable
  ‘tot_filt’
get_scaled_counts_bulk: no visible binding for global variable ‘nf’
get_scaled_counts_bulk: no visible binding for global variable ‘.’
get_scaled_counts_bulk: no visible binding for global variable ‘tot’
get_symbol_from_ensembl: no visible binding for global variable
  ‘ensembl_id’
get_symbol_from_ensembl: no visible binding for global variable
  ‘transcript’
get_symbol_from_ensembl: no visible binding for global variable
  ‘ref_genome’
get_tt_columns: no visible binding for global variable ‘tt_columns’
glmerCore: no visible global function definition for ‘coef’
glmerCore: no visible global function definition for ‘vcov’
glmerCore: no visible global function definition for ‘AIC’
glmerCore: no visible global function definition for ‘logLik’
glmerCore: no visible global function definition for ‘anova’
glmerCore: no visible global function definition for ‘predict’
glmmSeq: no visible global function definition for ‘update.formula’
glmmTMB_to_confidence_intervals_random_effects: no visible binding for
  global variable ‘group_id’
glmmTMB_to_confidence_intervals_random_effects: no visible binding for
  global variable ‘parameter’
glmmTMB_to_confidence_intervals_random_effects: no visible binding for
  global variable ‘CI’
glmmTMB_to_confidence_intervals_random_effects: no visible binding for
  global variable ‘lower’
glmmTMB_to_confidence_intervals_random_effects: no visible binding for
  global variable ‘upper’
glmmTMBcore: no visible global function definition for ‘coef’
glmmTMBcore: no visible global function definition for ‘vcov’
glmmTMBcore: no visible global function definition for ‘AIC’
glmmTMBcore: no visible global function definition for ‘logLik’
glmmTMBcore: no visible global function definition for ‘anova’
glmmTMBcore: no visible global function definition for ‘predict’
initialise_tt_internals: no visible binding for global variable ‘.’
lmer_to_confidence_intervals_random_effects: no visible binding for
  global variable ‘group_id’
lmer_to_confidence_intervals_random_effects: no visible binding for
  global variable ‘parameter’
lmer_to_confidence_intervals_random_effects: no visible binding for
  global variable ‘CI’
lmer_to_confidence_intervals_random_effects: no visible binding for
  global variable ‘lower’
lmer_to_confidence_intervals_random_effects: no visible binding for
  global variable ‘upper’
memorise_methods_used: no visible binding for global variable ‘.’
multivariable_differential_tissue_composition: no visible binding for
  global variable ‘.’
multivariable_differential_tissue_composition: no visible binding for
  global variable ‘.cell_type’
multivariable_differential_tissue_composition: no visible binding for
  global variable ‘term’
multivariable_differential_tissue_composition_SE: no visible binding
  for global variable ‘.’
multivariable_differential_tissue_composition_SE: no visible binding
  for global variable ‘.cell_type’
multivariable_differential_tissue_composition_SE: no visible binding
  for global variable ‘term’
remove_redundancy_elements_though_reduced_dimensions: no visible
  binding for global variable ‘sample b’
remove_redundancy_elements_though_reduced_dimensions: no visible
  binding for global variable ‘sample a’
remove_redundancy_elements_though_reduced_dimensions: no visible
  binding for global variable ‘sample 1’
remove_redundancy_elements_though_reduced_dimensions: no visible
  binding for global variable ‘sample 2’
remove_redundancy_elements_though_reduced_dimensions_SE: no visible
  binding for global variable ‘sample b’
remove_redundancy_elements_though_reduced_dimensions_SE: no visible
  binding for global variable ‘sample a’
remove_redundancy_elements_though_reduced_dimensions_SE: no visible
  binding for global variable ‘sample 1’
remove_redundancy_elements_though_reduced_dimensions_SE: no visible
  binding for global variable ‘sample 2’
remove_redundancy_elements_through_correlation: no visible binding for
  global variable ‘rc’
remove_redundancy_elements_through_correlation: no visible binding for
  global variable ‘transcript’
remove_redundancy_elements_through_correlation: no visible binding for
  global variable ‘correlation’
remove_redundancy_elements_through_correlation: no visible binding for
  global variable ‘item1’
remove_redundancy_elements_through_correlation_SE: no visible binding
  for global variable ‘abundance’
remove_redundancy_elements_through_correlation_SE: no visible binding
  for global variable ‘transcript’
remove_redundancy_elements_through_correlation_SE: no visible binding
  for global variable ‘element’
remove_redundancy_elements_through_correlation_SE: no visible binding
  for global variable ‘feature’
remove_redundancy_elements_through_correlation_SE: no visible binding
  for global variable ‘rc’
remove_redundancy_elements_through_correlation_SE: no visible binding
  for global variable ‘correlation’
remove_redundancy_elements_through_correlation_SE: no visible binding
  for global variable ‘item1’
resolve_complete_confounders_of_non_interest_pair_df: no visible
  binding for global variable ‘rowid’
resolve_complete_confounders_of_non_interest_pair_df: no visible global
  function definition for ‘desc’
resolve_complete_confounders_of_non_interest_pair_df: no visible
  binding for global variable ‘n1’
resolve_complete_confounders_of_non_interest_pair_df: no visible
  binding for global variable ‘n2’
resolve_complete_confounders_of_non_interest_pair_df: no visible
  binding for global variable ‘se_data’
rowwise.tidybulk: no visible binding for global variable ‘.data’
run_epic: no visible global function definition for ‘EPIC’
run_llsr: no visible binding for global variable ‘X_cibersort’
scale_design: no visible binding for global variable ‘value’
scale_design: no visible binding for global variable ‘sample_idx’
scale_design: no visible binding for global variable ‘(Intercept)’
select_closest_pairs: no visible binding for global variable ‘sample 1’
select_closest_pairs: no visible binding for global variable ‘sample 2’
subset_tibble_output: no visible binding for global variable ‘.’
symbol_to_entrez: no visible binding for global variable
  ‘transcript_upper’
symbol_to_entrez: no visible binding for global variable ‘entrez’
test_differential_cellularity: no visible binding for global variable
  ‘X_cibersort’
test_differential_cellularity_: no visible binding for global variable
  ‘cell_type’
test_differential_cellularity_: no visible binding for global variable
  ‘prop’
test_differential_cellularity_: no visible binding for global variable
  ‘.’
test_differential_cellularity_: no visible binding for global variable
  ‘.cell_type’
test_gene_enrichment_bulk_EGSEA: no visible global function definition
  for ‘buildCustomIdx’
test_gene_enrichment_bulk_EGSEA: no visible global function definition
  for ‘buildIdx’
test_gene_enrichment_bulk_EGSEA: no visible binding for global variable
  ‘pathway’
test_gene_enrichment_bulk_EGSEA: no visible binding for global variable
  ‘data_base’
test_gene_enrichment_bulk_EGSEA: no visible binding for global variable
  ‘web_page’
test_gene_enrichment_bulk_EGSEA: no visible global function definition
  for ‘egsea’
test_stratification_cellularity: no visible binding for global variable
  ‘X_cibersort’
test_stratification_cellularity_: no visible binding for global
  variable ‘.cell_type’
tidybulk_to_SummarizedExperiment: no visible binding for global
  variable ‘.’
univariable_differential_tissue_composition: no visible binding for
  global variable ‘.proportion’
univariable_differential_tissue_composition: no visible binding for
  global variable ‘.cell_type’
univariable_differential_tissue_composition: no visible binding for
  global variable ‘cell_type_proportions’
univariable_differential_tissue_composition: no visible binding for
  global variable ‘surv_test’
univariable_differential_tissue_composition_SE: no visible binding for
  global variable ‘.proportion’
univariable_differential_tissue_composition_SE: no visible binding for
  global variable ‘.cell_type’
univariable_differential_tissue_composition_SE: no visible binding for
  global variable ‘cell_type_proportions’
univariable_differential_tissue_composition_SE: no visible binding for
  global variable ‘surv_test’
univariable_differential_tissue_stratification: no visible binding for
  global variable ‘.cell_type’
univariable_differential_tissue_stratification: no visible binding for
  global variable ‘cell_type_proportions’
univariable_differential_tissue_stratification: no visible binding for
  global variable ‘surv_test’
univariable_differential_tissue_stratification_SE: no visible binding
  for global variable ‘.cell_type’
univariable_differential_tissue_stratification_SE: no visible binding
  for global variable ‘cell_type_proportions’
univariable_differential_tissue_stratification_SE: no visible binding
  for global variable ‘surv_test’
adjust_abundance,RangedSummarizedExperiment: no visible binding for
  global variable ‘x’
adjust_abundance,SummarizedExperiment: no visible binding for global
  variable ‘x’
aggregate_duplicates,RangedSummarizedExperiment: no visible binding for
  global variable ‘group_name’
aggregate_duplicates,RangedSummarizedExperiment: no visible binding for
  global variable ‘group’
aggregate_duplicates,SummarizedExperiment: no visible binding for
  global variable ‘group_name’
aggregate_duplicates,SummarizedExperiment: no visible binding for
  global variable ‘group’
describe_transcript,RangedSummarizedExperiment: no visible binding for
  global variable ‘transcript’
describe_transcript,RangedSummarizedExperiment: no visible binding for
  global variable ‘description’
describe_transcript,SummarizedExperiment: no visible binding for global
  variable ‘transcript’
describe_transcript,SummarizedExperiment: no visible binding for global
  variable ‘description’
identify_abundant,spec_tbl_df: no visible binding for global variable
  ‘.abundant’
identify_abundant,tbl_df: no visible binding for global variable
  ‘.abundant’
identify_abundant,tidybulk: no visible binding for global variable
  ‘.abundant’
keep_abundant,spec_tbl_df: no visible binding for global variable
  ‘.abundant’
keep_abundant,tbl_df: no visible binding for global variable
  ‘.abundant’
keep_abundant,tidybulk: no visible binding for global variable
  ‘.abundant’
pivot_sample,RangedSummarizedExperiment: no visible binding for global
  variable ‘.’
pivot_sample,SummarizedExperiment: no visible binding for global
  variable ‘.’
quantile_normalise_abundance,RangedSummarizedExperiment: no visible
  binding for global variable ‘x’
quantile_normalise_abundance,SummarizedExperiment: no visible binding
  for global variable ‘x’
quantile_normalise_abundance,spec_tbl_df: no visible binding for global
  variable ‘x’
quantile_normalise_abundance,tbl_df: no visible binding for global
  variable ‘x’
quantile_normalise_abundance,tidybulk: no visible binding for global
  variable ‘x’
resolve_complete_confounders_of_non_interest,RangedSummarizedExperiment:
  no visible global function definition for ‘DataFrame’
resolve_complete_confounders_of_non_interest,SummarizedExperiment: no
  visible global function definition for ‘DataFrame’
scale_abundance,RangedSummarizedExperiment: no visible binding for
  global variable ‘x’
scale_abundance,SummarizedExperiment: no visible binding for global
  variable ‘x’
scale_abundance,spec_tbl_df: no visible binding for global variable ‘x’
scale_abundance,spec_tbl_df: no visible binding for global variable
  ‘multiplier’
scale_abundance,tbl_df: no visible binding for global variable ‘x’
scale_abundance,tbl_df: no visible binding for global variable
  ‘multiplier’
scale_abundance,tidybulk: no visible binding for global variable ‘x’
scale_abundance,tidybulk: no visible binding for global variable
  ‘multiplier’
test_differential_cellularity,RangedSummarizedExperiment: no visible
  binding for global variable ‘X_cibersort’
test_differential_cellularity,RangedSummarizedExperiment: no visible
  binding for global variable ‘cell_type’
test_differential_cellularity,RangedSummarizedExperiment: no visible
  binding for global variable ‘prop’
test_differential_cellularity,RangedSummarizedExperiment: no visible
  binding for global variable ‘.cell_type’
test_differential_cellularity,SummarizedExperiment: no visible binding
  for global variable ‘X_cibersort’
test_differential_cellularity,SummarizedExperiment: no visible binding
  for global variable ‘cell_type’
test_differential_cellularity,SummarizedExperiment: no visible binding
  for global variable ‘prop’
test_differential_cellularity,SummarizedExperiment: no visible binding
  for global variable ‘.cell_type’
test_differential_cellularity,spec_tbl_df: no visible binding for
  global variable ‘X_cibersort’
test_differential_cellularity,tbl_df: no visible binding for global
  variable ‘X_cibersort’
test_differential_cellularity,tidybulk: no visible binding for global
  variable ‘X_cibersort’
test_gene_enrichment,RangedSummarizedExperiment: no visible global
  function definition for ‘buildCustomIdx’
test_gene_enrichment,RangedSummarizedExperiment: no visible global
  function definition for ‘buildIdx’
test_gene_enrichment,RangedSummarizedExperiment: no visible global
  function definition for ‘egsea’
test_gene_enrichment,RangedSummarizedExperiment: no visible binding for
  global variable ‘pathway’
test_gene_enrichment,RangedSummarizedExperiment: no visible binding for
  global variable ‘data_base’
test_gene_enrichment,RangedSummarizedExperiment: no visible binding for
  global variable ‘web_page’
test_gene_enrichment,SummarizedExperiment: no visible global function
  definition for ‘buildCustomIdx’
test_gene_enrichment,SummarizedExperiment: no visible global function
  definition for ‘buildIdx’
test_gene_enrichment,SummarizedExperiment: no visible global function
  definition for ‘egsea’
test_gene_enrichment,SummarizedExperiment: no visible binding for
  global variable ‘pathway’
test_gene_enrichment,SummarizedExperiment: no visible binding for
  global variable ‘data_base’
test_gene_enrichment,SummarizedExperiment: no visible binding for
  global variable ‘web_page’
test_gene_overrepresentation,RangedSummarizedExperiment: no visible
  binding for global variable ‘my_do_test’
test_gene_overrepresentation,SummarizedExperiment: no visible binding
  for global variable ‘my_do_test’
test_gene_overrepresentation,spec_tbl_df: no visible binding for global
  variable ‘my_do_test’
test_gene_overrepresentation,tbl_df: no visible binding for global
  variable ‘my_do_test’
test_gene_overrepresentation,tidybulk: no visible binding for global
  variable ‘my_do_test’
test_gene_rank,RangedSummarizedExperiment: no visible global function
  definition for ‘desc’
test_gene_rank,SummarizedExperiment: no visible global function
  definition for ‘desc’
test_gene_rank,spec_tbl_df: no visible global function definition for
  ‘with_groups’
test_gene_rank,spec_tbl_df: no visible global function definition for
  ‘desc’
test_gene_rank,tbl_df: no visible global function definition for
  ‘with_groups’
test_gene_rank,tbl_df: no visible global function definition for ‘desc’
test_gene_rank,tidybulk: no visible global function definition for
  ‘with_groups’
test_gene_rank,tidybulk: no visible global function definition for
  ‘desc’
test_stratification_cellularity,RangedSummarizedExperiment: no visible
  binding for global variable ‘X_cibersort’
test_stratification_cellularity,RangedSummarizedExperiment: no visible
  binding for global variable ‘.cell_type’
test_stratification_cellularity,SummarizedExperiment: no visible
  binding for global variable ‘X_cibersort’
test_stratification_cellularity,SummarizedExperiment: no visible
  binding for global variable ‘.cell_type’
test_stratification_cellularity,spec_tbl_df: no visible binding for
  global variable ‘X_cibersort’
test_stratification_cellularity,tbl_df: no visible binding for global
  variable ‘X_cibersort’
test_stratification_cellularity,tidybulk: no visible binding for global
  variable ‘X_cibersort’
Undefined global functions or variables:
  (Intercept) . .abundance_scaled .abundant .cell_type .contrasts .data
  .feature .proportion AIC CI Component Component value DataFrame EPIC
  GeneID NUL Status X_cibersort Y abundance action add_count all_of
  anova buildCustomIdx buildIdx cell_type cell_type_proportions cluster
  cluster kmeans coef combn correlation counts cov_data ct_data
  data_base desc description egsea element ends_with ensembl_id entrez
  feature fit geneID genes group group_id group_name gs_collection
  item1 library_size__ logLik lower m med multiplier my_do_test my_n n1
  n2 n_aggr name ncbi_gene nf nulldist packageVersion parameter pathway
  predict prop rc read count ref_genome rotated dimensions rowid sample
  1 sample 2 sample a sample b sample_idx samples sdev se_data
  seurat_clusters surv_test tagwise.dispersion temp term test tot
  tot_filt transcript transcript_upper tt_columns update.formula upper
  value variable vcov web_page where with_groups x
Consider adding
  importFrom("base", "sample")
  importFrom("stats", "AIC", "anova", "coef", "kmeans", "logLik",
             "predict", "update.formula", "vcov")
  importFrom("utils", "combn", "packageVersion")
to your NAMESPACE file.
* checking Rd files ... NOTE
checkRd: (-1) remove_redundancy-methods.Rd:158-175: Lost braces
   158 | select_closest_pairs = function(df) {
       |                                     ^
checkRd: (-1) remove_redundancy-methods.Rd:161-171: Lost braces
   161 |                 while (df |> nrow() > 0) {
       |                                          ^
checkRd: (-1) rotate_dimensions-methods.Rd:126-134: Lost braces
   126 |         rotation = function(m, d) {
       |                                   ^
checkRd: (-1) test_gene_overrepresentation-methods.Rd:114-116: Lost braces
   114 | if (!is.null(gene_collections)) {
       |                                 ^
* checking Rd metadata ... OK
* checking Rd cross-references ... NOTE
Non-topic package-anchored link(s) in Rd file 'pipe.Rd':
  ‘[magrittr:pipe]{%>%}’

See section 'Cross-references' in the 'Writing R Extensions' manual.
* checking for missing documentation entries ... OK
* checking for code/documentation mismatches ... OK
* checking Rd \usage sections ... OK
* checking Rd contents ... OK
* checking for unstated dependencies in examples ... OK
* checking contents of ‘data’ directory ... OK
* checking data for non-ASCII characters ... OK
* checking LazyData ... OK
* checking data for ASCII and uncompressed saves ... OK
* checking files in ‘vignettes’ ... OK
* checking examples ... OK
Examples with CPU (user + system) or elapsed time > 5s
                                          user system elapsed
test_differential_abundance-methods     53.436  0.455  54.126
test_differential_cellularity-methods   11.338  0.122  11.530
test_stratification_cellularity-methods  6.542  0.066   6.656
adjust_abundance-methods                 5.501  0.130   5.664
deconvolve_cellularity-methods           5.113  0.050   5.193
* checking for unstated dependencies in ‘tests’ ... OK
* checking tests ...
  Running ‘testthat.R’
 ERROR
Running the tests in ‘tests/testthat.R’ failed.
Last 13 lines of output:
  nrow(...) not equal to 97.
  1/1 mismatches
  [1] 100 - 97 == 3
  ── Failure ('test-bulk_methods_SummarizedExperiment.R:496:3'): Voom with treat method ──
  nrow(...) not equal to 294.
  1/1 mismatches
  [1] 293 - 294 == -1
  ── Failure ('test-bulk_methods_SummarizedExperiment.R:501:3'): Voom with treat method ──
  nrow(...) not equal to 246.
  1/1 mismatches
  [1] 248 - 246 == 2
  
  [ FAIL 8 | WARN 49 | SKIP 3 | PASS 219 ]
  Error: Test failures
  Execution halted
* checking for unstated dependencies in vignettes ... OK
* checking package vignettes ... OK
* checking running R code from vignettes ... SKIPPED
* checking re-building of vignette outputs ... SKIPPED
* checking PDF version of manual ... OK
* DONE

Status: 1 ERROR, 3 NOTEs
See
  ‘/Users/biocbuild/bbs-3.22-bioc/meat/tidybulk.Rcheck/00check.log’
for details.

##############################################################################
##############################################################################
###
### Running command:
###
###   /Library/Frameworks/R.framework/Resources/bin/R CMD INSTALL tidybulk
###
##############################################################################
##############################################################################


* installing to library ‘/Library/Frameworks/R.framework/Versions/4.5-x86_64/Resources/library’
* installing *source* package ‘tidybulk’ ...
** this is package ‘tidybulk’ version ‘1.21.0’
** using staged installation
** R
** data
*** moving datasets to lazyload DB
** inst
** byte-compile and prepare package for lazy loading
Note: wrong number of arguments to 'expm1' 
Note: wrong number of arguments to 'expm1' 
Note: wrong number of arguments to 'expm1' 
Note: wrong number of arguments to 'expm1' 
Note: wrong number of arguments to 'expm1' 
Note: wrong number of arguments to 'expm1' 
Note: wrong number of arguments to 'expm1' 
Note: wrong number of arguments to 'floor' 
Note: wrong number of arguments to 'floor' 
** help
*** installing help indices
*** copying figures
** building package indices
** installing vignettes
** testing if installed package can be loaded from temporary location
** testing if installed package can be loaded from final location
** testing if installed package keeps a record of temporary installation path
* DONE (tidybulk)

R version 4.5.1 (2025-06-13) -- "Great Square Root"
Copyright (C) 2025 The R Foundation for Statistical Computing
Platform: x86_64-apple-darwin20

R is free software and comes with ABSOLUTELY NO WARRANTY.
You are welcome to redistribute it under certain conditions.
Type 'license()' or 'licence()' for distribution details.

R is a collaborative project with many contributors.
Type 'contributors()' for more information and
'citation()' on how to cite R or R packages in publications.

Type 'demo()' for some demos, 'help()' for on-line help, or
'help.start()' for an HTML browser interface to help.
Type 'q()' to quit R.

> library(testthat)
> library(tidybulk)
Loading required package: ttservice
========================================
tidybulk version 1.21.0
If you use TIDYBULK in published research, please cite:

Mangiola et al. tidybulk: an R tidy framework for modular 
transcriptomic data analysis. Genome Biology 2021.

This message can be suppressed by:
  suppressPackageStartupMessages(library(tidybulk))
========================================


Attaching package: 'tidybulk'

The following object is masked from 'package:stats':

    filter

> 
> test_check("tidybulk")
Coefficients not estimable: conditionTRUE 
Coefficients not estimable: conditionTRUE 
Time difference of 3.825784 secs
Time difference of 3.790055 secs
Found 2 batches
Using null model in ComBat-seq.
Adjusting for 1 covariate(s) or covariate level(s)
Estimating dispersions
Fitting the GLM model
Apply shrinkage - computing posterior estimates for parameters
Using 100 random genes for Monte Carlo integration
Adjusting the data
Found 2 batches
Using null model in ComBat-seq.
Adjusting for 1 covariate(s) or covariate level(s)
Estimating dispersions
Fitting the GLM model
Apply shrinkage - computing posterior estimates for parameters
Using 100 random genes for Monte Carlo integration
Adjusting the data
Found 2 batches
Using null model in ComBat-seq.
Adjusting for 1 covariate(s) or covariate level(s)
Estimating dispersions
Fitting the GLM model
Apply shrinkage - computing posterior estimates for parameters
Using 100 random genes for Monte Carlo integration
Adjusting the data
Time difference of 20.83485 secs
Time difference of 11.38814 secs
Performing PCA
Read the 251 x 50 data matrix successfully!
Using no_dims = 2, perplexity = 30.000000, and theta = 0.500000
Computing input similarities...
Building tree...
Done in 0.03 seconds (sparsity = 0.490437)!
Learning embedding...
Iteration 50: error is 56.834157 (50 iterations in 0.03 seconds)
Iteration 100: error is 56.732697 (50 iterations in 0.03 seconds)
Iteration 150: error is 55.922411 (50 iterations in 0.04 seconds)
Iteration 200: error is 57.052878 (50 iterations in 0.04 seconds)
Iteration 250: error is 58.806430 (50 iterations in 0.04 seconds)
Iteration 300: error is 1.025754 (50 iterations in 0.04 seconds)
Iteration 350: error is 0.791635 (50 iterations in 0.03 seconds)
Iteration 400: error is 0.773477 (50 iterations in 0.02 seconds)
Iteration 450: error is 0.771416 (50 iterations in 0.03 seconds)
Iteration 500: error is 0.771506 (50 iterations in 0.03 seconds)
Iteration 550: error is 0.771514 (50 iterations in 0.02 seconds)
Iteration 600: error is 0.771162 (50 iterations in 0.02 seconds)
Iteration 650: error is 0.769619 (50 iterations in 0.02 seconds)
Iteration 700: error is 0.769150 (50 iterations in 0.03 seconds)
Iteration 750: error is 0.768945 (50 iterations in 0.02 seconds)
Iteration 800: error is 0.769068 (50 iterations in 0.03 seconds)
Iteration 850: error is 0.769748 (50 iterations in 0.03 seconds)
Iteration 900: error is 0.769973 (50 iterations in 0.03 seconds)
Iteration 950: error is 0.771254 (50 iterations in 0.02 seconds)
Iteration 1000: error is 0.771193 (50 iterations in 0.02 seconds)
Fitting performed in 0.56 seconds.
[ FAIL 8 | WARN 49 | SKIP 3 | PASS 219 ]

══ Skipped tests (3) ═══════════════════════════════════════════════════════════
• empty test (3): 'test-bulk_methods.R:1064:1',
  'test-tximeta_GRnges_IRanges.R:3:1', 'test-tximeta_GRnges_IRanges.R:19:1'

══ Failed tests ════════════════════════════════════════════════════════════════
── Failure ('test-bulk_methods.R:450:2'): Only differential trancript abundance voom - no object ──
unique(res$logFC)[1:4] not equal to c(-3.659127, -3.233295, -3.75086, -3.033059).
4/4 mismatches (average diff: 0.332)
[1] -3.71 - -3.66 == -0.0468
[2] -3.29 - -3.23 == -0.0580
[3] -3.14 - -3.75 ==  0.6150
[4] -3.64 - -3.03 == -0.6079
── Failure ('test-bulk_methods.R:475:2'): Only differential trancript abundance voom - no object ──
unique(res$logFC)[1:4] not equal to c(-2.981563, -4.883692, -1.702294, 2.423231).
4/4 mismatches (average diff: 1.97)
[1] -3.13 - -2.98 == -0.146
[2] -1.68 - -4.88 ==  3.203
[3] -1.50 - -1.70 ==  0.201
[4] -1.93 -  2.42 == -4.350
── Failure ('test-bulk_methods.R:572:2'): Voom with treat method ───────────────
nrow(...) not equal to 97.
1/1 mismatches
[1] 100 - 97 == 3
── Failure ('test-bulk_methods.R:603:6'): Voom with treat method ───────────────
nrow(...) not equal to 294.
1/1 mismatches
[1] 293 - 294 == -1
── Failure ('test-bulk_methods.R:608:6'): Voom with treat method ───────────────
nrow(...) not equal to 246.
1/1 mismatches
[1] 248 - 246 == 2
── Failure ('test-bulk_methods_SummarizedExperiment.R:470:3'): Voom with treat method ──
nrow(...) not equal to 97.
1/1 mismatches
[1] 100 - 97 == 3
── Failure ('test-bulk_methods_SummarizedExperiment.R:496:3'): Voom with treat method ──
nrow(...) not equal to 294.
1/1 mismatches
[1] 293 - 294 == -1
── Failure ('test-bulk_methods_SummarizedExperiment.R:501:3'): Voom with treat method ──
nrow(...) not equal to 246.
1/1 mismatches
[1] 248 - 246 == 2

[ FAIL 8 | WARN 49 | SKIP 3 | PASS 219 ]
Error: Test failures
Execution halted