mlumr: Multilevel Unanchored Meta-Regression for Indirect Treatment Comparisons
Bayesian multilevel unanchored meta-regression (ML-UMR) for indirect treatment comparisons using individual patient data (IPD) and aggregate data (AgD). Implements shared prognostic factor assumption (SPFA) and relaxed SPFA models for binary, continuous, and count outcomes via 'Stan'. Also provides simulated treatment comparison (STC) via parametric G-computation and naive unadjusted benchmarks. ML-UMR is an adaptation of the ML-NMR methodology (Phillippo et al. 2020, <doi:10.1111/rssa.12579>) implemented in the 'multinma' package (GPL-3) to the unanchored two-trial case; the public API deliberately mirrors multinma's so users can move between ML-NMR and ML-UMR with the same workflow.
| Version: | 0.1.0 |
| Depends: | R (≥ 4.1.0) |
| Imports: | methods, stats, Rcpp (≥ 0.12.0), RcppParallel (≥ 5.0.1), rstan (≥ 2.26.0), rstantools (≥ 2.3.0), randtoolbox, copula |
| LinkingTo: | BH (≥ 1.66.0), Rcpp (≥ 0.12.0), RcppEigen (≥ 0.3.3.3.0), RcppParallel (≥ 5.0.1), rstan (≥ 2.26.0), StanHeaders (≥ 2.26.0) |
| Suggests: | testthat (≥ 3.0.0), knitr, rmarkdown, posterior, bayesplot, loo, Matrix, cmdstanr, withr |
| Published: | 2026-05-20 |
| DOI: | 10.32614/CRAN.package.mlumr (may not be active yet) |
| Author: | Ahmad Sofi-Mahmudi
 [aut, cre],
Conor Chandler
[aut] |
| Maintainer: | Ahmad Sofi-Mahmudi <a.sofimahmudi at gmail.com> |
| BugReports: | https://github.com/choxos/mlumr/issues |
| License: | GPL-3 |
| URL: | https://github.com/choxos/mlumr, https://choxos.github.io/mlumr/ |
| NeedsCompilation: | yes |
| SystemRequirements: | GNU make |
| Additional_repositories: | https://stan-dev.r-universe.dev |
| Citation: | mlumr citation info |
| Materials: | NEWS |
| CRAN checks: | mlumr results |
Documentation:
| Reference manual: | mlumr.html , mlumr.pdf |
| Vignettes: |
Data Preparation and Integration (source, R code) Introduction to mlumr (source, R code) Fitting ML-UMR Models (source) Comparing ML-UMR, STC, and Naive Methods (source) STC and Naive Benchmarks (source) Worked Example: Complete Analysis (source) |
Downloads:
| Package source: | mlumr_0.1.0.tar.gz |
| Windows binaries: | r-devel: not available, r-release: not available, r-oldrel: not available |
| macOS binaries: | r-release (arm64): not available, r-oldrel (arm64): not available, r-release (x86_64): not available, r-oldrel (x86_64): not available |
Linking:
Please use the canonical form https://CRAN.R-project.org/package=mlumr to link to this page.