
*************************************** 
 Population Fisher Matrix 
*************************************** 

                        μ_V          μ_Cl      μ_kout      μ_Imax      μ_IC50     μ_gamma         ω²_V        ω²_Cl      ω²_kout      ω²_Imax    ω²_IC50   ω²_gamma σ_slope_RespPK σ_inter_RespPD
μ_V            583.89694102    9.19036099 -0.02315464 -3.35612090  0.32079096 -0.24507445 0.000000e+00 0.000000e+00 0.000000e+00  0.000000000  0.0000000 0.00000000   0.000000e+00    0.000000000
μ_Cl             9.19036099 2110.23408215 -0.01715815 -0.03198433  0.52533166  0.35319017 0.000000e+00 0.000000e+00 0.000000e+00  0.000000000  0.0000000 0.00000000   0.000000e+00    0.000000000
μ_kout          -0.02315464   -0.01715815  1.04306085  0.63336569 -0.03141002 -0.04209541 0.000000e+00 0.000000e+00 0.000000e+00  0.000000000  0.0000000 0.00000000   0.000000e+00    0.000000000
μ_Imax          -3.35612090   -0.03198433  0.63336569 60.63827631 -2.70317529  1.54206818 0.000000e+00 0.000000e+00 0.000000e+00  0.000000000  0.0000000 0.00000000   0.000000e+00    0.000000000
μ_IC50           0.32079096    0.52533166 -0.03141002 -2.70317529  0.65184243  0.07044445 0.000000e+00 0.000000e+00 0.000000e+00  0.000000000  0.0000000 0.00000000   0.000000e+00    0.000000000
μ_gamma         -0.24507445    0.35319017 -0.04209541  1.54206818  0.07044445  0.74226627 0.000000e+00 0.000000e+00 0.000000e+00  0.000000000  0.0000000 0.00000000   0.000000e+00    0.000000000
ω²_V             0.00000000    0.00000000  0.00000000  0.00000000  0.00000000  0.00000000 1.419936e+03 5.071130e-02 5.312959e-04  0.174193007  0.4767726 0.01121281   1.694963e+02    0.022484025
ω²_Cl            0.00000000    0.00000000  0.00000000  0.00000000  0.00000000  0.00000000 5.071130e-02 3.801555e+02 9.340249e-05  0.003376237  0.1153787 0.00215635   3.442924e+01    0.004590882
ω²_kout          0.00000000    0.00000000  0.00000000  0.00000000  0.00000000  0.00000000 5.312959e-04 9.340249e-05 2.149292e+01  0.386744465  0.1693550 0.01150713   8.462700e-03    0.050138553
ω²_Imax          0.00000000    0.00000000  0.00000000  0.00000000  0.00000000  0.00000000 1.741930e-01 3.376237e-03 3.867445e-01 41.669312017 16.1932689 0.55767351   1.413532e+00    0.818888973
ω²_IC50          0.00000000    0.00000000  0.00000000  0.00000000  0.00000000  0.00000000 4.767726e-01 1.153787e-01 1.693550e-01 16.193268935 83.8259799 0.15388072   8.155428e+00    1.229640291
ω²_gamma         0.00000000    0.00000000  0.00000000  0.00000000  0.00000000  0.00000000 1.121281e-02 2.156350e-03 1.150713e-02  0.557673507  0.1538807 0.69850714   1.549203e-01    0.107175844
σ_slope_RespPK   0.00000000    0.00000000  0.00000000  0.00000000  0.00000000  0.00000000 1.694963e+02 3.442924e+01 8.462700e-03  1.413531724  8.1554276 0.15492032   1.146177e+04    0.328767259
σ_inter_RespPD   0.00000000    0.00000000  0.00000000  0.00000000  0.00000000  0.00000000 2.248402e-02 4.590882e-03 5.013855e-02  0.818888973  1.2296403 0.10717584   3.287673e-01    5.297969806

*************************************** 
 Fixed effects 
*************************************** 

                 μ_V          μ_Cl      μ_kout      μ_Imax      μ_IC50     μ_gamma
μ_V     583.89694102    9.19036099 -0.02315464 -3.35612090  0.32079096 -0.24507445
μ_Cl      9.19036099 2110.23408215 -0.01715815 -0.03198433  0.52533166  0.35319017
μ_kout   -0.02315464   -0.01715815  1.04306085  0.63336569 -0.03141002 -0.04209541
μ_Imax   -3.35612090   -0.03198433  0.63336569 60.63827631 -2.70317529  1.54206818
μ_IC50    0.32079096    0.52533166 -0.03141002 -2.70317529  0.65184243  0.07044445
μ_gamma  -0.24507445    0.35319017 -0.04209541  1.54206818  0.07044445  0.74226627

*************************************** 
 Variance components 
*************************************** 

                       ω²_V        ω²_Cl      ω²_kout      ω²_Imax    ω²_IC50   ω²_gamma σ_slope_RespPK σ_inter_RespPD
ω²_V           1.419936e+03 5.071130e-02 5.312959e-04  0.174193007  0.4767726 0.01121281   1.694963e+02    0.022484025
ω²_Cl          5.071130e-02 3.801555e+02 9.340249e-05  0.003376237  0.1153787 0.00215635   3.442924e+01    0.004590882
ω²_kout        5.312959e-04 9.340249e-05 2.149292e+01  0.386744465  0.1693550 0.01150713   8.462700e-03    0.050138553
ω²_Imax        1.741930e-01 3.376237e-03 3.867445e-01 41.669312017 16.1932689 0.55767351   1.413532e+00    0.818888973
ω²_IC50        4.767726e-01 1.153787e-01 1.693550e-01 16.193268935 83.8259799 0.15388072   8.155428e+00    1.229640291
ω²_gamma       1.121281e-02 2.156350e-03 1.150713e-02  0.557673507  0.1538807 0.69850714   1.549203e-01    0.107175844
σ_slope_RespPK 1.694963e+02 3.442924e+01 8.462700e-03  1.413531724  8.1554276 0.15492032   1.146177e+04    0.328767259
σ_inter_RespPD 2.248402e-02 4.590882e-03 5.013855e-02  0.818888973  1.2296403 0.10717584   3.287673e-01    5.297969806

********************************************* 
 Determinant, condition numbers and D-criterion  
*********************************************** 

Determinant: 4.24689711411024e+22 
D-criterion: 41.332420450232 
Condition number of the fixed effects: 4677.28366293334 
Condition number of the random effects: 16644.2310751313 

*************************************** 
 Parameters estimation 
*************************************** 

               parametersValues          SE       RSE
μ_V                    0.740000 0.041396101  5.594068
μ_Cl                   0.280000 0.021772569  7.775917
μ_kout                 6.140000 0.984617978 16.036123
μ_Imax                 0.760000 0.149908136 19.724755
μ_IC50                 9.220000 1.409222187 15.284406
μ_gamma                2.770000 1.227830929 44.326026
ω²_V                   0.099856 0.026561314 26.599617
ω²_Cl                  0.207936 0.051295421 24.668851
ω²_kout                0.896809 0.215721035 24.054290
ω²_Imax                0.192721 0.162032545 84.076227
ω²_IC50                0.204304 0.113693973 55.649411
ω²_gamma               3.101121 1.204551613 38.842458
σ_slope_RespPK         0.210000 0.009350449  4.452595
σ_inter_RespPD         9.600000 0.436125367  4.542973
